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Qing-Long Guo Selected Research

gambogic acid

8/2012Studies on chemical structure modification and structure-activity relationship of derivatives of gambogic acid at C(39).
10/2010Gambogic acid triggers DNA damage signaling that induces p53/p21(Waf1/CIP1) activation through the ATR-Chk1 pathway.
10/2009Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53.
2/2009Synergistic effect of 5-fluorouracil with gambogic acid on BGC-823 human gastric carcinoma.
7/2008Inhibition of alpha(4) integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with gambogic acid.
7/2008Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cells.
4/2008Posttranscriptional regulation of the telomerase hTERT by gambogic acid in human gastric carcinoma 823 cells.
3/2008Inhibition of glioblastoma growth and angiogenesis by gambogic acid: an in vitro and in vivo study.
10/2007Differential apoptotic induction of gambogic acid, a novel anticancer natural product, on hepatoma cells and normal hepatocytes.
3/2007Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells.
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Qing-Long Guo Research Topics

Disease

48Neoplasms (Cancer)
04/2022 - 10/2002
17Hepatocellular Carcinoma (Hepatoma)
04/2022 - 10/2002
10Carcinoma (Carcinomatosis)
07/2012 - 07/2004
7Breast Neoplasms (Breast Cancer)
02/2020 - 07/2008
4Neoplasm Metastasis (Metastasis)
03/2022 - 07/2008
4Carcinogenesis
04/2019 - 06/2008
4Sarcoma (Soft Tissue Sarcoma)
05/2016 - 06/2006
4Leukemia
08/2015 - 04/2008
4Colonic Neoplasms (Colon Cancer)
02/2014 - 06/2008
3Glioblastoma (Glioblastoma Multiforme)
01/2022 - 03/2008
3Inflammation (Inflammations)
10/2014 - 10/2013
3Stomach Neoplasms (Stomach Cancer)
09/2010 - 06/2005
2BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia)
02/2021 - 02/2020
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
07/2017 - 09/2007
2Hypoxia (Hypoxemia)
02/2014 - 05/2013
2Melanoma (Melanoma, Malignant)
01/2014 - 07/2008
2Liver Neoplasms (Liver Cancer)
12/2008 - 06/2008
2Sarcoma 180
06/2008 - 10/2002
1Osteosarcoma (Osteogenic Sarcoma)
08/2016
1Multiple Myeloma
02/2016
1Bronchiolo-Alveolar Adenocarcinoma (Adenocarcinoma, Bronchiolo Alveolar)
06/2015
1Lung Injury
10/2014
1Necrosis
10/2014
1Acute Lung Injury
10/2014
1Gastrointestinal Neoplasms (Gastrointestinal Cancer)
01/2014
1Colorectal Neoplasms (Colorectal Cancer)
08/2012
1Adenocarcinoma
07/2012

Drug/Important Bio-Agent (IBA)

15gambogic acidIBA
08/2012 - 07/2004
14wogoninIBA
02/2021 - 06/2006
125,7- dihydroxy- 6- methoxy- 2- phenylchromen- 4- oneIBA
04/2022 - 12/2006
6Proteins (Proteins, Gene)FDA Link
02/2014 - 07/2004
5Biological ProductsIBA
03/2022 - 03/2007
5FlavonoidsIBA
02/2020 - 12/2006
5EnzymesIBA
10/2013 - 06/2008
5Fluorouracil (Carac)FDA LinkGeneric
08/2013 - 02/2009
4Doxorubicin (Adriamycin)FDA LinkGeneric
08/2016 - 06/2008
4Telomerase (Telomerase Reverse Transcriptase)IBA
04/2008 - 11/2004
3Member 1 Subfamily B ATP Binding Cassette TransporterIBA
08/2016 - 10/2005
3Small Interfering RNA (siRNA)IBA
05/2016 - 05/2013
3Messenger RNA (mRNA)IBA
05/2013 - 11/2004
3Pharmaceutical PreparationsIBA
08/2012 - 09/2010
2IntegrinsIBA
04/2019 - 07/2008
2NF-kappa B (NF-kB)IBA
10/2014 - 09/2010
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2013 - 04/2008
2Antineoplastic Agents (Antineoplastics)IBA
10/2012 - 10/2006
2Reactive Oxygen Species (Oxygen Radicals)IBA
10/2011 - 10/2010
2baicaleinIBA
11/2010 - 03/2004
2LYG 202IBA
10/2010 - 08/2009
2DNA (Deoxyribonucleic Acid)IBA
09/2009 - 03/2004
1Cyclin-Dependent Kinase 9IBA
04/2022
1Sirtuin 1IBA
04/2022
1Transforming Growth Factor beta1 (TGF beta 1)IBA
03/2022
1Cell Adhesion MoleculesIBA
04/2019
1Immune Checkpoint InhibitorsIBA
01/2018
1Transcription Factors (Transcription Factor)IBA
11/2016
1MK 2206IBA
08/2016
1Endoplasmic Reticulum Chaperone BiPIBA
08/2016
1baohuoside IIBA
05/2016
1TOR Serine-Threonine KinasesIBA
05/2016
1aspafilioside BIBA
05/2016
1p38 Mitogen-Activated Protein KinasesIBA
05/2016
1CateninsIBA
05/2016
1Daunorubicin (Cerubidine)FDA LinkGeneric
08/2015
1Pregnane X ReceptorIBA
08/2015
1hydroxycitric acidIBA
08/2015
1VimentinIBA
06/2015
1Cadherins (E-Cadherin)IBA
06/2015
1PPAR gammaIBA
10/2014
1LipopolysaccharidesIBA
10/2014
1CytokinesIBA
10/2014
1Interleukin-6 (Interleukin 6)IBA
10/2014
1Peroxisome Proliferator-Activated Receptors (PPAR)IBA
10/2014
12-chloro-5-nitrobenzanilideIBA
10/2014
1Paclitaxel (Taxol)FDA LinkGeneric
02/2014
1Tissue ExtractsIBA
05/2013
1benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA
05/2013
1LuciferasesIBA
05/2013
1BromidesIBA
08/2012
1diphenyl (biphenyl)IBA
08/2012
1Red DND-99IBA
04/2012
1Platinum Compounds (Compounds, Platinum)IBA
04/2012
1E platinumIBA
04/2012
1Fluorescein-5-isothiocyanate (FITC)IBA
04/2012
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
04/2012
1Annexin A1IBA
01/2012
1CalreticulinIBA
01/2012
1HMGB1 Protein (HMG1)IBA
01/2012
1VaccinesIBA
01/2012
1NCPMF-60IBA
01/2011
1Drug CombinationsIBA
09/2010
1SaponinsIBA
07/2009
1hederageninIBA
07/2009

Therapy/Procedure

10Therapeutics
04/2022 - 03/2008
3Drug Therapy (Chemotherapy)
10/2011 - 10/2005
2Chinese Traditional Medicine (Traditional Chinese Medicine)
06/2015 - 06/2005
2Chemoprevention
02/2014 - 07/2012
2Transplantation
06/2004 - 03/2004
1Aftercare (After-Treatment)
05/2016
1Oral Administration
07/2012
1Immunotherapy
01/2012